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KMID : 0605620080150040288
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Journal of Korean Society of Biological Psychiatry
2008 Volume.15 No. 4 p.288 ~ p.296
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No Association between Val108/158Met Polymorphism on Catechol-O-Methyl Transferase(COMT) Gene and Smooth Pursuit Eye Movement(SPEM) Abnormality in Korean Schizophrenia Patients
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Jang Ho-Joon
Moon Hyun-Il
Lee Yeon-Jung
Kim Im-Yel
Lee In-Sang
Seo Han-Gil
Kim Ki-Hoon
Shin Tae-Min
Park Byung-Rae
Shin Hyoung-Doo
Han Sun-Ho
Han Sang-Woo
Woo Sung-Il
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Abstract
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Objectives：We investigated the association of Val108/158Met polymorphism on catechol-O-methyl transferase(
COMT) gene with smooth pursuit eye movement(SPEM) abnormality in Korean schizophrenia patients.
Methods：We measured SPEM in 217 Korean schizophrenia patients(male 116, female 101) and divided them into two groups, one was a good SPEM function group and the other was a poor SPEM function group. Then we analyzed Val108/158Met polymorphism on COMT gene. We compared the differences of genotype and allele distributions of the polymorphism on COMT gene between the two groups.
Results：The natural logarithm value of signal/noise ratio(Ln S/N ratio) of the good SPEM function group was
4.39±0.33(mean±s.d.) and that of poor SPEM function group was 3.17±0.71. There were no statistically significant differences of age and male/female ratio between the two groups. There were no significant differences of genotype or allele distributions of the Val108/158Met polymorphism on COMT gene between the two schizophrenic groups.
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KEYWORD
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Schizophrenia, Catechol-O-methyl transferase(COMT), Smooth pursuit eye movement(SPEM), Genetic polymorphism.
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